Flagyl ER (metronidazole extended-release) is a prescription antibiotic and antiprotozoal medication designed to combat a range of serious bacterial and parasitic infections. Its advanced extended-release formulation ensures sustained therapeutic levels in the body, enhancing efficacy while potentially reducing dosing frequency. It is specifically indicated for the treatment of bacterial vaginosis in adult women and other anaerobic infections, providing a trusted option under medical supervision. Always use this medication exactly as directed by your healthcare provider to achieve optimal results and minimize risks.

Features

• Contains metronidazole as the active ingredient in an extended-release tablet form
• Designed for once-daily dosing to improve patient adherence
• Formulated to provide consistent drug release over several hours
• Available in 750 mg strength tablets
• Requires a prescription and professional medical diagnosis for use
• Manufactured under strict quality control standards for potency and purity

Benefits

• Effectively treats bacterial vaginosis with a convenient once-daily regimen
• Extended-release action maintains therapeutic levels for consistent infection control
• Reduces the frequency of dosing, which may minimize the risk of missed doses
• Helps alleviate symptoms such as odor, discharge, and discomfort
• Targets anaerobic bacteria and certain parasites directly at the infection site
• Supported by extensive clinical use and research in infectious disease management

Common use

Flagyl ER is primarily prescribed for the treatment of bacterial vaginosis in non-pregnant adult women. It may also be used off-label or in specific cases for other anaerobic bacterial infections, such as intra-abdominal infections, skin and soft tissue infections, bone and joint infections, and certain parasitic infections like amebiasis and trichomoniasis, when determined appropriate by a healthcare provider. It is not typically used for viral or fungal infections.

Dosage and direction

The standard dosage for Flagyl ER in the treatment of bacterial vaginosis is one 750 mg tablet taken orally once daily for 7 consecutive days. Tablets should be swallowed whole with a full glass of water; do not crush, chew, or split the tablet. It is best taken on an empty stomach, at least 1 hour before or 2 hours after meals, to maximize absorption. Follow your healthcare provider’s instructions precisely regarding duration and timing, even if symptoms improve before finishing the course.

Precautions

Before taking Flagyl ER, inform your healthcare provider of any history of blood disorders, liver disease, kidney dysfunction, nervous system disorders, or seizures. Avoid alcohol consumption during treatment and for at least 3 days after completion due to the risk of a disulfiram-like reaction (nausea, vomiting, flushing, tachycardia). Use with caution in elderly patients and those with Crohn’s disease or a history of Candida overgrowth. Not recommended during pregnancy or breastfeeding unless clearly needed and under medical advice.

Contraindications

Flagyl ER is contraindicated in patients with a known hypersensitivity to metronidazole, other nitroimidazole derivatives, or any component of the formulation. It should not be used during the first trimester of pregnancy. Avoid in patients with active organic neurologic diseases or a history of blood dyscrasias. Concomitant use with disulfiram or alcohol is contraindicated due to potential adverse interactions.

Possible side effect

Common side effects may include nausea, headache, dry mouth, metallic taste, dizziness, and gastrointestinal discomfort. Less frequently, patients may experience vomiting, diarrhea, constipation, darkened urine, or peripheral neuropathy. Serious side effects, though rare, can include seizures, encephalopathy, pancreatitis, or severe allergic reactions. Contact your healthcare provider promptly if you experience persistent or worsening symptoms.

Drug interaction

Flagyl ER may interact with warfarin and other anticoagulants, increasing the risk of bleeding. Concurrent use with disulfiram, alcohol, or alcohol-containing products can cause severe reactions. It may elevate levels of lithium, phenytoin, and cyclosporine, necessitating monitoring. Caution is advised with other medications that inhibit CYP450 enzymes. Always inform your prescriber of all medications, supplements, and herbal products you are taking.

Missed dose

If you miss a dose of Flagyl ER, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular schedule. Do not double the dose to catch up, as this may increase the risk of side effects. Consistency is important for effectiveness, so try to adhere closely to the prescribed timing.

Overdose

Symptoms of overdose may include severe nausea, vomiting, ataxia, seizures, and peripheral neuropathy. In case of suspected overdose, seek immediate medical attention or contact a poison control center. Treatment is typically supportive and may include gastric lavage or activated charcoal if ingestion was recent. There is no specific antidote for metronidazole overdose.

Storage

Store Flagyl ER tablets at room temperature (20–25°C or 68–77°F), in a dry place, away from light and moisture. Keep the medication in its original container, tightly closed, and out of reach of children and pets. Do not store in bathrooms or near sinks. Dispose of any unused or expired medication properly according to local guidelines or through a drug take-back program.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before starting or changing any medication regimen. Do not disregard or delay seeking medical advice based on content provided here. Individual patient needs and circumstances may vary.

Reviews

Flagyl ER is generally well-regarded in clinical settings for its efficacy in treating bacterial vaginosis and anaerobic infections. Healthcare professionals appreciate the extended-release formulation for improving patient compliance. Some users report effective symptom relief, though experiences with side effects like gastrointestinal discomfort or metallic taste vary. Always discuss your specific condition and treatment response with your prescriber.